“Fucked needs to mean more than that something is complicated or must be undertaken with thought and care, as that would be trivially true of everything in science. In this class we will go a step further and say that something is fucked if it presents hard conceptual challenges to which implementable, real-world solutions for working scientists are either not available or routinely ignored in practice.”
—Sanjay Srivastava. “Everything is Fucked: The Syllabus.” TheHardestScience.com. August 11, 2016.