Biohacking: Smart People With Money Being Science-Based and Stupid 

“Over the last 4–5 years, my main hobby has been to get that by hacking my body and mind using a logical, science-based approach…

…People like me will be able to pay for this out of pocket and use off-label prescriptions from private doctors who focus on upgrading and prevention rather than merely healing. Downstream the extra mood, energy, focus, health, willpower and social skills — enhanced over decades — will accrue further and further advantages to people who upgrade themselves, which will lead to a cycle of further concentration of wealth.”

—Serge Faguet, “I’m 32 and spent $200k on biohacking. Became calmer, thinner, extroverted, healthier & happier.hackernoon.com. September 25, 2017.

N of 1 experimentation is valuable. The problem in this case is he is arguing hockey stick, compounding returns when the more likely scenario is that he’s going to give himself some form of chronic illness over the long-term. You’re only 32. Do you believe 40 years of thyroid supplementation isn’t going to lead to a health problem?

There is useful advice in write-ups such as this one. Thinking about sleep hygiene, eliminating sugar from your diet, intermittent fasting, weight-training built around deadlifts and squats, HITT training for cardio, meditation/cognitive therapy are probably all good ideas.

The place it goes off the rails is with medications and supplements. A low dose of 5mg of lithium is probably alright. If you take ~100-150mg as he is, you better have normal kidney function. Magnesium supplementation is also probably a good idea, since most of us aren’t eating big leafy vegetables at the same rate our ancestors did.

I could even get behind the very occasional therapeutic use of psychoactive compounds such as MDMA, psilocybin mushrooms, LSD, etc. If they were used to to augment a program of meditation and periodic hours in an isolation tank.

But hormone therapy? Playing sorcerer’s apprentice with your hormones strikes me as a singularly bad idea.

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