A one-sheet on posture toward the people around you The principle, and its known failure Jon Postel wrote it for computers talking to each other: send strictly correct output, accept anything you can reasonably interpret. It let a fragile early internet work despite everyone's software being slightly wrong. Engineers later turned against it. Broken implementations … Continue reading Be Conservative in What You Send, Liberal in What You Receive
Tag: incentives
Generalizing the 5/10/15 Rule for U.S. Drug Development, Or The Cycle of the New
"U.S. drug development cycle, which he says “always follows the 5/10/15 rule. For the first 5 years, companies hype new drugs; next 5 years all hidden side effects are exposed, leading to black-box warnings and class action lawsuits; in [the] last 5 years, the companies start dissing their own old drug as the patent runs … Continue reading Generalizing the 5/10/15 Rule for U.S. Drug Development, Or The Cycle of the New
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